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Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B
Numerical aberration of the centrosome results in chromosome missegregation, eventually leading to chromosomal instability, a hallmark of human tumor malignancy. Large tumor suppressors 1 and 2 (Lats1 and Lats2) are central kinases in the Hippo pathway and regulate development and tumorigenesis by c...
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| Foilsithe in: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Nature Publishing Group
2015
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4632022/ https://ncbi.nlm.nih.gov/pubmed/26530630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep16173 |
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