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LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer

Cancer stem cells (CSCs), which play important roles in tumor initiation and progression, are resistant to many types of therapies. However, the regulatory mechanisms underlying CSC-specific properties, including self-renewal, are poorly understood. Here, we found that LATS1/2, the core Hippo pathwa...

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發表在:Oncotarget
Main Authors: Nozaki, Masami, Yabuta, Norikazu, Fukuzawa, Moe, Mukai, Satomi, Okamoto, Ayumi, Sasakura, Towa, Fukushima, Kohshiro, Naito, Yoko, Longmore, Gregory D., Nojima, Hiroshi
格式: Artigo
語言:Inglês
出版: Impact Journals LLC 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383686/
https://ncbi.nlm.nih.gov/pubmed/30800215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26583
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