LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer

Cancer stem cells (CSCs), which play important roles in tumor initiation and progression, are resistant to many types of therapies. However, the regulatory mechanisms underlying CSC-specific properties, including self-renewal, are poorly understood. Here, we found that LATS1/2, the core Hippo pathwa...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Nozaki, Masami, Yabuta, Norikazu, Fukuzawa, Moe, Mukai, Satomi, Okamoto, Ayumi, Sasakura, Towa, Fukushima, Kohshiro, Naito, Yoko, Longmore, Gregory D., Nojima, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2019
Assuntos:
Priority Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6383686/
https://ncbi.nlm.nih.gov/pubmed/30800215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26583
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