CDKN2B loss promotes progression from benign melanocytic nevus to melanoma

Deletion of the entire CDKN2B-CDKN2A gene cluster is among the most common genetic events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A-encoded p16 and p14ARF tumor suppressors. The degree to which the associated CDKN2B-encoded p15 loss contributes to human tumori...

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Vydáno v:Cancer Discov
Hlavní autoři: McNeal, Andrew S., Liu, Kevin, Nakhate, Vihang, Natale, Christopher A., Duperret, Elizabeth K., Capell, Brian C., Dentchev, Tzvete, Berger, Shelley L., Herlyn, Meenhard, Seykora, John T., Ridky, Todd W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4592422/
https://ncbi.nlm.nih.gov/pubmed/26183406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0196
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