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Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

Cyclin-dependent kinase 2 (CDK2) has been proposed to function as a master regulator of centrosome duplication. Using mouse embryonic fibroblasts (MEFs) in which Cdk2 has been genetically deleted, we show here that CDK2 is not required for normal centrosome duplication, maturation and bipolar mitoti...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Duensing, Anette, Liu, Ying, Tseng, Michelle, Malumbres, Marcos, Barbacid, Mariano, Duensing, Stefan
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2006
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225596/
https://ncbi.nlm.nih.gov/pubmed/16331279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1209310
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