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Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

Cyclin-dependent kinase 2 (CDK2) has been proposed to function as a master regulator of centrosome duplication. Using mouse embryonic fibroblasts (MEFs) in which Cdk2 has been genetically deleted, we show here that CDK2 is not required for normal centrosome duplication, maturation and bipolar mitoti...

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Detalles Bibliográficos
Main Authors: Duensing, Anette, Liu, Ying, Tseng, Michelle, Malumbres, Marcos, Barbacid, Mariano, Duensing, Stefan
Formato: Artigo
Idioma:Inglês
Publicado: 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2225596/
https://ncbi.nlm.nih.gov/pubmed/16331279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1209310
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