Tripeptidyl Peptidase II Is Required for c-MYC–Induced Centriole Overduplication and a Novel Therapeutic Target in c-MYC–Associated Neoplasms

Centrosome aberrations are frequently detected in c-MYC–associated human malignancies. Here, we show that c-MYC–induced centrosome and centriole overduplication critically depend on the protease tripeptidyl peptidase II (TPPII). We found that TPPII localizes to centrosomes and that overexpression of...

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Detalhes bibliográficos
Main Authors: Duensing, Stefan, Darr, Sebastian, Cuevas, Rolando, Melquiot, Nadja, Brickner, Anthony G., Duensing, Anette, Münger, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2010
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3092256/
https://ncbi.nlm.nih.gov/pubmed/21647238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1947601910389605
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