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Loss of Both CDKN2A and CDKN2B Allows for Centrosome Overduplication in Melanoma
Centrosomes duplicate only once in coordination with the DNA replication cycle and have an important role in segregating genetic material. In contrast, most cancer cells have centrosome aberrations, including supernumerary centrosomes, and this correlates with aneuploidy and genetic instability. The...
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| Publicado no: | J Invest Dermatol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7435684/ https://ncbi.nlm.nih.gov/pubmed/32067956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.01.024 |
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