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Mitochondria-lysosome contacts regulate mitochondrial Ca(2+) dynamics via lysosomal TRPML1

Mitochondria and lysosomes are critical for cellular homeostasis, and dysfunction of both organelles has been implicated in numerous diseases. Recently, interorganelle contacts between mitochondria and lysosomes were identified and found to regulate mitochondrial dynamics. However, whether mitochond...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Peng, Wesley, Wong, Yvette C., Krainc, Dimitri
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7430993/
https://ncbi.nlm.nih.gov/pubmed/32703809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003236117
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