Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression

Studies indicate that mutant α-synuclein (mαSyn) is involved in the pathogenesis of Parkinson’s disease (PD). The mαSyn expression leads to the loss of dopaminergic neurons in the substantia nigra (SN) and consequent motor dysfunctions. Additionally, studies found that PD was accompanied by extensiv...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Aging (Albany NY)
Hauptverfasser: Wang, Yong, Wang, Qian, Yu, Ruobing, Zhang, Qi, Zhang, Zhonghai, Li, Haiying, Ren, Chao, Yang, Rongli, Niu, Haichen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425448/
https://ncbi.nlm.nih.gov/pubmed/32706757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103440
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge