Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative disease characterized by intraneuronal Lewy Body (LB) aggregates composed of misfolded alpha-synuclein (α-syn). The spread of misfolded α-syn follows a typical pattern: starting in the olfactory bulb (OB) and the gut, this pathology is foll...

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Udgivet i:Transl Neurodegener
Main Authors: Niu, Haichen, Shen, Lingyu, Li, Tongzhou, Ren, Chao, Ding, Sheng, Wang, Lei, Zhang, Zhonghai, Liu, Xiaoyu, Zhang, Qiang, Geng, Deqin, Wu, Xiujuan, Li, Haiying
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192070/
https://ncbi.nlm.nih.gov/pubmed/30356861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-018-0128-6
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