Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

Parkinson’s disease (PD) is characterized by the progressive appearance of intraneuronal Lewy aggregates, which are primarily composed of misfolded α-synuclein (α-syn). The aggregates are believed to propagate via neural pathways following a stereotypical pattern, starting in the olfactory bulb (OB)...

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Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Rey, Nolwen L., Steiner, Jennifer A., Maroof, Nazia, Luk, Kelvin C., Madaj, Zachary, Trojanowski, John Q., Lee, Virginia M.-Y., Brundin, Patrik
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2016
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995088/
https://ncbi.nlm.nih.gov/pubmed/27503075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160368
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