Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression

Studies indicate that mutant α-synuclein (mαSyn) is involved in the pathogenesis of Parkinson’s disease (PD). The mαSyn expression leads to the loss of dopaminergic neurons in the substantia nigra (SN) and consequent motor dysfunctions. Additionally, studies found that PD was accompanied by extensiv...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Aging (Albany NY)
Päätekijät: Wang, Yong, Wang, Qian, Yu, Ruobing, Zhang, Qi, Zhang, Zhonghai, Li, Haiying, Ren, Chao, Yang, Rongli, Niu, Haichen
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Impact Journals 2020
Aiheet:
Research Paper
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425448/
https://ncbi.nlm.nih.gov/pubmed/32706757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103440
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