Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression

Studies indicate that mutant α-synuclein (mαSyn) is involved in the pathogenesis of Parkinson’s disease (PD). The mαSyn expression leads to the loss of dopaminergic neurons in the substantia nigra (SN) and consequent motor dysfunctions. Additionally, studies found that PD was accompanied by extensiv...

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Vydáno v:Aging (Albany NY)
Hlavní autoři: Wang, Yong, Wang, Qian, Yu, Ruobing, Zhang, Qi, Zhang, Zhonghai, Li, Haiying, Ren, Chao, Yang, Rongli, Niu, Haichen
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals 2020
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425448/
https://ncbi.nlm.nih.gov/pubmed/32706757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103440
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