Minocycline inhibition of microglial rescues nigrostriatal dopaminergic neurodegeneration caused by mutant alpha-synuclein overexpression

Studies indicate that mutant α-synuclein (mαSyn) is involved in the pathogenesis of Parkinson’s disease (PD). The mαSyn expression leads to the loss of dopaminergic neurons in the substantia nigra (SN) and consequent motor dysfunctions. Additionally, studies found that PD was accompanied by extensiv...

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Bibliografiske detaljer
Udgivet i:Aging (Albany NY)
Main Authors: Wang, Yong, Wang, Qian, Yu, Ruobing, Zhang, Qi, Zhang, Zhonghai, Li, Haiying, Ren, Chao, Yang, Rongli, Niu, Haichen
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425448/
https://ncbi.nlm.nih.gov/pubmed/32706757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103440
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