Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

Parkinson's disease is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. We now report that minocycline, a semisynthetic tetracycline, recently shown to...

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Autors principals: Du, Yansheng, Ma, Zhizhong, Lin, Suizhen, Dodel, Richard C., Gao, Feng, Bales, Kelly R., Triarhou, Lazarose C., Chernet, Eyassu, Perry, Ken W., Nelson, David L. G., Luecke, Susan, Phebus, Lee A., Bymaster, Frank P., Paul, Steven M.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC64739/
https://ncbi.nlm.nih.gov/pubmed/11724929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251341998
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