Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

Parkinson's disease is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. We now report that minocycline, a semisynthetic tetracycline, recently shown to...

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Main Authors: Du, Yansheng, Ma, Zhizhong, Lin, Suizhen, Dodel, Richard C., Gao, Feng, Bales, Kelly R., Triarhou, Lazarose C., Chernet, Eyassu, Perry, Ken W., Nelson, David L. G., Luecke, Susan, Phebus, Lee A., Bymaster, Frank P., Paul, Steven M.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2001
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC64739/
https://ncbi.nlm.nih.gov/pubmed/11724929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251341998
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