Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

Parkinson's disease is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. We now report that minocycline, a semisynthetic tetracycline, recently shown to...

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Autori principali: Du, Yansheng, Ma, Zhizhong, Lin, Suizhen, Dodel, Richard C., Gao, Feng, Bales, Kelly R., Triarhou, Lazarose C., Chernet, Eyassu, Perry, Ken W., Nelson, David L. G., Luecke, Susan, Phebus, Lee A., Bymaster, Frank P., Paul, Steven M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences 2001
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC64739/
https://ncbi.nlm.nih.gov/pubmed/11724929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251341998
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