Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

Parkinson's disease is a chronic neurodegenerative disorder characterized by the loss of dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and consequent extrapyramidal motor dysfunction. We now report that minocycline, a semisynthetic tetracycline, recently shown to...

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Bibliographische Detailangaben
Hauptverfasser: Du, Yansheng, Ma, Zhizhong, Lin, Suizhen, Dodel, Richard C., Gao, Feng, Bales, Kelly R., Triarhou, Lazarose C., Chernet, Eyassu, Perry, Ken W., Nelson, David L. G., Luecke, Susan, Phebus, Lee A., Bymaster, Frank P., Paul, Steven M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC64739/
https://ncbi.nlm.nih.gov/pubmed/11724929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251341998
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