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Megakaryocytes promote osteoclastogenesis in aging

Megakaryocytes (MKs) support bone formation by stimulating osteoblasts (OBs) and inhibiting osteoclasts (OCs). Aging results in higher bone resorption, leading to bone loss. Whereas previous studies showed the effects of aging on MK-mediated bone formation, the effects of aging on MK-mediated OC for...

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Dades bibliogràfiques
Publicat a:Aging (Albany NY)
Autors principals: Kanagasabapathy, Deepa, Blosser, Rachel J., Maupin, Kevin A., Hong, Jung Min, Alvarez, Marta, Ghosh, Joydeep, Mohamad, Safa F., Aguilar-Perez, Alexandra, Srour, Edward F., Kacena, Melissa A., Bruzzaniti, Angela
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7425434/
https://ncbi.nlm.nih.gov/pubmed/32634116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/aging.103595
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