Aging Negatively Impacts the Ability of Megakaryocytes to Stimulate Osteoblast Proliferation and Bone Mass

Osteoblast number and activity decreases with aging, contributing to the age-associated decline of bone mass, but the mechanisms underlying changes in osteoblast activity are not well understood. Here, we show that the age-associated bone loss critically depends on impairment of the ability of megak...

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Veröffentlicht in:Bone
Hauptverfasser: Maupin, Kevin A., Himes, Evan R., Plett, Artur P., Chua, Hui Lin, Singh, Pratibha, Ghosh, Joydeep, Mohamad, Safa F., Abeysekera, Irushi, Fisher, Alexa, Sampson, Carol, Hong, Jung-Min, Childress, Paul, Alvarez, Marta, Srour, Edward F., Bruzzaniti, Angela, Pelus, Louis M., Orschell, Christie M., Kacena, Melissa A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6708771/
https://ncbi.nlm.nih.gov/pubmed/31299382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2019.07.010
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