Lnk Deficiency leads to TPO-Mediated Osteoclastogenesis and Increased Bone Mass Phenotype

The Lnk adapter protein negatively regulates the signaling of thrombopoietin (TPO), the main megakaryocyte (MK) growth factor. Lnk-deficient (−/−) mice have increased TPO signaling and increased MK number. Interestingly, several mouse models exist in which increased MK number leads to a high bone ma...

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Veröffentlicht in:J Cell Biochem
Hauptverfasser: Olivos, David J., Alvarez, Marta, Cheng, Ying-Hua, Hooker, R. Adam, Ciovacco, Wendy A., Bethel, Monique, McGough, Haley, Yim, Christopher, Chitteti, Brahmananda R., Eleniste, Pierre P., Horowitz, Mark C., Srour, Edward F., Bruzzaniti, Angela, Fuchs, Robyn K., Kacena, Melissa A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562279/
https://ncbi.nlm.nih.gov/pubmed/28067429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25874
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