C-Mpl is expressed on osteoblasts and osteoclasts and is important in regulating skeletal homeostasis

C-Mpl is the receptor for thrombopoietin (TPO), the main megakaryocyte (MK) growth factor, and c-Mpl is believed to be expressed on cells of the hematopoietic lineage. As MKs have been shown to enhance bone formation, it may be expected that mice in which c-Mpl was globally knocked out (c-Mpl−/− mic...

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Publicat a:J Cell Biochem
Autors principals: Meijome, Tomas E., Baughman, Jenna T., Hooker, R. Adam, Cheng, Ying-Hua, Ciovacco, Wendy A., Balamohan, Sanjeev M., Srinivasan, Trishya L., Chitteti, Brahmananda R., Eleniste, Pierre P., Horowitz, Mark C., Srour, Edward F., Bruzzaniti, Angela, Fuchs, Robyn K., Kacena, Melissa A.
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4883670/
https://ncbi.nlm.nih.gov/pubmed/26375403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25380
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