Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease

Sickle cell disease (SCD), which afflicts 100 000 Americans, as well as millions worldwide, is associated with anemia, lifelong morbidity, and early mortality. Abnormal adhesion of sickle red blood cells (RBCs) to activated vascular endothelium may contribute acutely to the initiation of painful vas...

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Bibliographic Details
Published in:Blood Adv
Main Authors: Kucukal, Erdem, Man, Yuncheng, Quinn, Erina, Tewari, Neil, An, Ran, Ilich, Anton, Key, Nigel S., Little, Jane A., Gurkan, Umut A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2020
Subjects:
Red Cells, Iron, and Erythropoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422136/
https://ncbi.nlm.nih.gov/pubmed/32777069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001656
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