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Red Blood Cell Adhesion to Heme-Activated Endothelial Cells Reflects Clinical Phenotype in Sickle Cell Disease

In sickle cell disease (SCD), ‘disease severity’ associates with increased RBC adhesion to quiescent endothelium, but the impact on activated endothelium is not known. Increased concentrations of free heme result from intravascular hemolysis in SCD. Heme is essential for aerobic metabolism, and play...

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Bibliografische gegevens
Gepubliceerd in:Am J Hematol
Hoofdauteurs: Kucukal, Erdem, Ilich, Anton, Key, Nigel S., Little, Jane A., Gurkan, Umut A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295270/
https://ncbi.nlm.nih.gov/pubmed/29905377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.25159
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