Red blood cell adhesion to ICAM-1 is mediated by fibrinogen and is associated with right-to-left shunts in sickle cell disease

Sickle cell disease (SCD), which afflicts 100 000 Americans, as well as millions worldwide, is associated with anemia, lifelong morbidity, and early mortality. Abnormal adhesion of sickle red blood cells (RBCs) to activated vascular endothelium may contribute acutely to the initiation of painful vas...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Kucukal, Erdem, Man, Yuncheng, Quinn, Erina, Tewari, Neil, An, Ran, Ilich, Anton, Key, Nigel S., Little, Jane A., Gurkan, Umut A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2020
Soggetti:
Red Cells, Iron, and Erythropoiesis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7422136/
https://ncbi.nlm.nih.gov/pubmed/32777069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020001656
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