Standardized microfluidic assessment of red blood cell mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease

OBJECTIVES: We present a standardized in vitro microfluidic assay and Occlusion Index (OI) for the assessment of red blood cell (RBC)-mediated microcapillary occlusion and its clinical associations in sickle cell disease (SCD). METHODS: RBC-mediated microcapillary occlusion represented by OI and its...

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Bibliographic Details
Published in:Microcirculation
Main Authors: Man, Yuncheng, Kucukal, Erdem, An, Ran, Bode, Allison, Little, Jane A., Gurkan, Umut A.
Format: Artigo
Language:Inglês
Published: 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7920910/
https://ncbi.nlm.nih.gov/pubmed/33025653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/micc.12662
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