Leukocyte adhesion to P-selectin and the inhibitory role of Crizanlizumab in sickle cell disease: a standardized microfluidic assessment

Upregulated expression of P-selectin on activated endothelium and platelets significantly contributes to the initiation and progression of vaso-occlusive crises (VOC), a major cause of morbidity in sickle cell disease (SCD). Crizanlizumab (ADAKVEO®), a humanized monoclonal antibody against P-selecti...

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Détails bibliographiques
Publié dans:Blood Cells Mol Dis
Auteurs principaux: Man, Yuncheng, Goreke, Utku, Kucukal, Erdem, Hill, Ailis, An, Ran, Liu, Shichen, Bode, Allison, Solis-Fuentes, Ambar, Nayak, Lalitha V., Little, Jane A., Gurkan, Umut A.
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7246173/
https://ncbi.nlm.nih.gov/pubmed/32208292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2020.102424
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