A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer

Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and transferred to the Golgi complex by interaction with the Batten disease protein CLN8 (ceroid lipofuscinosis, neuronal, 8). Here we investigated the relationship of this pathway with CLN6, an ER-associated protein of unknown func...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Bajaj, Lakshya, Sharma, Jaiprakash, di Ronza, Alberto, Zhang, Pengcheng, Eblimit, Aiden, Pal, Rituraj, Roman, Dany, Collette, John R., Booth, Clarissa, Chang, Kevin T., Sifers, Richard N., Jung, Sung Y., Weimer, Jill M., Chen, Rui, Schekman, Randy W., Sardiello, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410054/
https://ncbi.nlm.nih.gov/pubmed/32597833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130955
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