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Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER–Golgi intermediate compartment

Triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein expressed on microglia within the brain. Several rare mutations in TREM2 cause an early-onset form of neurodegeneration when inherited homozygously. Here we investigate how these mutations affect the intracellular tr...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Sirkis, Daniel W., Aparicio, Renan E., Schekman, Randy
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620379/
https://ncbi.nlm.nih.gov/pubmed/28768830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-06-0423
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