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The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

Autophagy is a catabolic process for bulk degradation of cytosolic materials mediated by double-membraned autophagosomes. The membrane determinant to initiate the formation of autophagosomes remains elusive. Here, we establish a cell-free assay based on LC3 lipidation to define the organelle membran...

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Hlavní autoři: Ge, Liang, Melville, David, Zhang, Min, Schekman, Randy
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3736544/
https://ncbi.nlm.nih.gov/pubmed/23930225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00947
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