CLN8 is an ER cargo receptor that regulates lysosome biogenesis

Organelle biogenesis requires proper transport of proteins from their site of synthesis to their target subcellular compartment(1–3). Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and traffic through the Golgi complex before being transferred to the endolysosomal system(4–6), b...

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Pubblicato in:Nat Cell Biol
Autori principali: di Ronza, Alberto, Bajaj, Lakshya, Sharma, Jaiprakash, Sanagasetti, Deepthi, Lotfi, Parisa, Adamski, Carolyn Joy, Collette, John, Palmieri, Michela, Amawi, Abdallah, Popp, Lauren, Chang, Kevin Tommy, Meschini, Maria Chiara, Leung, Hon-Chiu Eastwood, Segatori, Laura, Simonati, Alessandro, Sifers, Richard Norman, Santorelli, Filippo Maria, Sardiello, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277210/
https://ncbi.nlm.nih.gov/pubmed/30397314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41556-018-0228-7
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