A CLN6-CLN8 complex recruits lysosomal enzymes at the ER for Golgi transfer

Lysosomal enzymes are synthesized in the endoplasmic reticulum (ER) and transferred to the Golgi complex by interaction with the Batten disease protein CLN8 (ceroid lipofuscinosis, neuronal, 8). Here we investigated the relationship of this pathway with CLN6, an ER-associated protein of unknown func...

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書誌詳細
出版年:J Clin Invest
主要な著者: Bajaj, Lakshya, Sharma, Jaiprakash, di Ronza, Alberto, Zhang, Pengcheng, Eblimit, Aiden, Pal, Rituraj, Roman, Dany, Collette, John R., Booth, Clarissa, Chang, Kevin T., Sifers, Richard N., Jung, Sung Y., Weimer, Jill M., Chen, Rui, Schekman, Randy W., Sardiello, Marco
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2020
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410054/
https://ncbi.nlm.nih.gov/pubmed/32597833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130955
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