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Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

Mutations affecting DNA polymerase exonuclease domains or mismatch repair (MMR) generate “mutator” phenotypes capable of driving tumorigenesis. Cancers with both defects exhibit an explosive increase in mutation burden that appears to reach a threshold, consistent with selection acting against furth...

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Xehetasun bibliografikoak
Argitaratua izan da:Genetics
Egile Nagusiak: Tracy, Maxwell A., Lee, Mitchell B., Hearn, Brady L., Dowsett, Ian T., Thurber, Luke C., Loo, Jason, Loeb, Anisha M., Preston, Kent, Tuncel, Miles I., Ghodsian, Niloufar, Bode, Anna, Tang, Thao T., Chia, Andy R., Herr, Alan J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Genetics Society of America 2020
Gaiak:
Investigations
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404223/
https://ncbi.nlm.nih.gov/pubmed/32513814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303333
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