Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

Mutations affecting DNA polymerase exonuclease domains or mismatch repair (MMR) generate “mutator” phenotypes capable of driving tumorigenesis. Cancers with both defects exhibit an explosive increase in mutation burden that appears to reach a threshold, consistent with selection acting against furth...

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Publicado en:Genetics
Autores principales: Tracy, Maxwell A., Lee, Mitchell B., Hearn, Brady L., Dowsett, Ian T., Thurber, Luke C., Loo, Jason, Loeb, Anisha M., Preston, Kent, Tuncel, Miles I., Ghodsian, Niloufar, Bode, Anna, Tang, Thao T., Chia, Andy R., Herr, Alan J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Genetics Society of America 2020
Materias:
Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404223/
https://ncbi.nlm.nih.gov/pubmed/32513814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303333
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