Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

Mutations affecting DNA polymerase exonuclease domains or mismatch repair (MMR) generate “mutator” phenotypes capable of driving tumorigenesis. Cancers with both defects exhibit an explosive increase in mutation burden that appears to reach a threshold, consistent with selection acting against furth...

詳細記述

保存先:
書誌詳細
出版年:Genetics
主要な著者: Tracy, Maxwell A., Lee, Mitchell B., Hearn, Brady L., Dowsett, Ian T., Thurber, Luke C., Loo, Jason, Loeb, Anisha M., Preston, Kent, Tuncel, Miles I., Ghodsian, Niloufar, Bode, Anna, Tang, Thao T., Chia, Andy R., Herr, Alan J.
フォーマット: Artigo
言語:Inglês
出版事項: Genetics Society of America 2020
主題:
Investigations
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404223/
https://ncbi.nlm.nih.gov/pubmed/32513814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303333
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料