Spontaneous Polyploids and Antimutators Compete During the Evolution of Saccharomyces cerevisiae Mutator Cells

Mutations affecting DNA polymerase exonuclease domains or mismatch repair (MMR) generate “mutator” phenotypes capable of driving tumorigenesis. Cancers with both defects exhibit an explosive increase in mutation burden that appears to reach a threshold, consistent with selection acting against furth...

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Dettagli Bibliografici
Pubblicato in:Genetics
Autori principali: Tracy, Maxwell A., Lee, Mitchell B., Hearn, Brady L., Dowsett, Ian T., Thurber, Luke C., Loo, Jason, Loeb, Anisha M., Preston, Kent, Tuncel, Miles I., Ghodsian, Niloufar, Bode, Anna, Tang, Thao T., Chia, Andy R., Herr, Alan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Genetics Society of America 2020
Soggetti:
Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404223/
https://ncbi.nlm.nih.gov/pubmed/32513814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.120.303333
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