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Antimutator Variants of DNA Polymerases

Evolution balances DNA replication speed and accuracy to optimize replicative fitness and genetic stability. There is no selective pressure to improve DNA replication fidelity beyond the background mutation rate from other sources, such as DNA damage. However, DNA polymerases remain amenable to amin...

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Detalhes bibliográficos
Main Authors: Herr, Alan J., Williams, Lindsey N., Preston, Bradley D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725746/
https://ncbi.nlm.nih.gov/pubmed/21977975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10409238.2011.620941
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