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Emergence of DNA Polymerase ε Antimutators That Escape Error-Induced Extinction in Yeast

DNA polymerases (Pols) ε and δ perform the bulk of yeast leading- and lagging-strand DNA synthesis. Both Pols possess intrinsic proofreading exonucleases that edit errors during polymerization. Rare errors that elude proofreading are extended into duplex DNA and excised by the mismatch repair (MMR)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Williams, Lindsey N., Herr, Alan J., Preston, Bradley D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583996/
https://ncbi.nlm.nih.gov/pubmed/23307893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.112.146910
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