DNA Replication Error-Induced Extinction of Diploid Yeast

Genetic defects in DNA polymerase accuracy, proofreading, or mismatch repair (MMR) induce mutator phenotypes that accelerate adaptation of microbes and tumor cells. Certain combinations of mutator alleles synergistically increase mutation rates to levels that drive extinction of haploid cells. The m...

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Bibliographic Details
Main Authors: Herr, Alan J., Kennedy, Scott R., Knowels, Gary M., Schultz, Eric M., Preston, Bradley D.
Format: Artigo
Language:Inglês
Published: Genetics Society of America 2014
Subjects:
Investigations
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948800/
https://ncbi.nlm.nih.gov/pubmed/24388879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.160960
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