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DNA Replication Error-Induced Extinction of Diploid Yeast
Genetic defects in DNA polymerase accuracy, proofreading, or mismatch repair (MMR) induce mutator phenotypes that accelerate adaptation of microbes and tumor cells. Certain combinations of mutator alleles synergistically increase mutation rates to levels that drive extinction of haploid cells. The m...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Genetics Society of America
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3948800/ https://ncbi.nlm.nih.gov/pubmed/24388879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.160960 |
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