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DNA Replication Error-Induced Extinction of Diploid Yeast

Genetic defects in DNA polymerase accuracy, proofreading, or mismatch repair (MMR) induce mutator phenotypes that accelerate adaptation of microbes and tumor cells. Certain combinations of mutator alleles synergistically increase mutation rates to levels that drive extinction of haploid cells. The m...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Herr, Alan J., Kennedy, Scott R., Knowels, Gary M., Schultz, Eric M., Preston, Bradley D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Genetics Society of America 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948800/
https://ncbi.nlm.nih.gov/pubmed/24388879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.160960
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