Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast

Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous mutation and facilitates cellular adaptation. However, double mutants are inviable, suggesting that extreme mutation rates exceed an error thresho...

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Detalhes bibliográficos
Main Authors: Herr, Alan J., Ogawa, Masanori, Lawrence, Nicole A., Williams, Lindsey N., Eggington, Julie M., Singh, Mallika, Smith, Robert A., Preston, Bradley D.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188538/
https://ncbi.nlm.nih.gov/pubmed/22022273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002282
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