Mutator Suppression and Escape from Replication Error–Induced Extinction in Yeast

Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous mutation and facilitates cellular adaptation. However, double mutants are inviable, suggesting that extreme mutation rates exceed an error thresho...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Herr, Alan J., Ogawa, Masanori, Lawrence, Nicole A., Williams, Lindsey N., Eggington, Julie M., Singh, Mallika, Smith, Robert A., Preston, Bradley D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188538/
https://ncbi.nlm.nih.gov/pubmed/22022273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002282
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