BNIP-2 retards breast cancer cell migration by coupling microtubule-mediated GEF-H1 and RhoA activation

Microtubules display dynamic turnover during cell migration, leading to cell contractility and focal adhesion maturation regulated by Rho guanosine triphosphatase activity. This interplay between microtubules and actomyosin is mediated by guanine nucleotide exchange factor (GEF)–H1 released after mi...

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Detalles Bibliográficos
Publicado en:Sci Adv
Autores principales: Pan, Meng, Chew, Ti Weng, Wong, Darren Chen Pei, Xiao, Jingwei, Ong, Hui Ting, Chin, Jasmine Fei Li, Low, Boon Chuan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Association for the Advancement of Science 2020
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399486/
https://ncbi.nlm.nih.gov/pubmed/32789168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz1534
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