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Oncogenic RAS isoforms show a hierarchical requirement for SOS2 to drive transformation
About a third of tumors harbor activating mutations in HRAS, NRAS, or KRAS, genes encoding guanine triphosphatases (GTPases) of the RAS family. In these tumors, wild-type RAS signaling cooperates with mutant RAS to promote downstream effector activation. This cooperation between wild-type and mutant...
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| Pubblicato in: | Sci Signal |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7396125/ https://ncbi.nlm.nih.gov/pubmed/30181243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aar8371 |
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