Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

The Ras GTPases are frequently mutated in human cancer, and, although the Raf kinases are essential effectors of Ras signaling, the tumorigenic properties of specific Ras-Raf complexes are not well characterized. Here, we examine the ability of individual Ras and Raf proteins to interact in live cel...

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Udgivet i:Mol Cell
Main Authors: Terrell, Elizabeth M., Durrant, David E., Ritt, Daniel A., Sealover, Nancy E., Sheffels, Erin, Spencer-Smith, Russell, Esposito, Dominic, Zhou, Yong, Hancock, John F., Kortum, Robert L., Morrison, Deborah K.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001861/
https://ncbi.nlm.nih.gov/pubmed/31606273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.004
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