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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

The Ras GTPases are frequently mutated in human cancer, and, although the Raf kinases are essential effectors of Ras signaling, the tumorigenic properties of specific Ras-Raf complexes are not well characterized. Here, we examine the ability of individual Ras and Raf proteins to interact in live cel...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Cell
Κύριοι συγγραφείς: Terrell, Elizabeth M., Durrant, David E., Ritt, Daniel A., Sealover, Nancy E., Sheffels, Erin, Spencer-Smith, Russell, Esposito, Dominic, Zhou, Yong, Hancock, John F., Kortum, Robert L., Morrison, Deborah K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2019
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001861/
https://ncbi.nlm.nih.gov/pubmed/31606273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.004
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