Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling

The Ras GTPases are frequently mutated in human cancer, and, although the Raf kinases are essential effectors of Ras signaling, the tumorigenic properties of specific Ras-Raf complexes are not well characterized. Here, we examine the ability of individual Ras and Raf proteins to interact in live cel...

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Bibliografiset tiedot
Julkaisussa:Mol Cell
Päätekijät: Terrell, Elizabeth M., Durrant, David E., Ritt, Daniel A., Sealover, Nancy E., Sheffels, Erin, Spencer-Smith, Russell, Esposito, Dominic, Zhou, Yong, Hancock, John F., Kortum, Robert L., Morrison, Deborah K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2019
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7001861/
https://ncbi.nlm.nih.gov/pubmed/31606273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.004
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