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Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling
The Ras GTPases are frequently mutated in human cancer, and, although the Raf kinases are essential effectors of Ras signaling, the tumorigenic properties of specific Ras-Raf complexes are not well characterized. Here, we examine the ability of individual Ras and Raf proteins to interact in live cel...
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| Udgivet i: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7001861/ https://ncbi.nlm.nih.gov/pubmed/31606273 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.09.004 |
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