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The Role of Wild-Type RAS in Oncogenic RAS Transformation

The RAS family of oncogenes (HRAS, NRAS, and KRAS) are among the most frequently mutated protein families in cancers. RAS-mutated tumors were originally thought to proliferate independently of upstream signaling inputs, but we now know that non-mutated wild-type (WT) RAS proteins play an important r...

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Detalhes bibliográficos
Publicado no:Genes (Basel)
Main Authors: Sheffels, Erin, Kortum, Robert L.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8146411/
https://ncbi.nlm.nih.gov/pubmed/33924994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes12050662
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