Marked synergy by vertical inhibition of EGFR signaling in NSCLC spheroids shows SOS1 is a therapeutic target in EGFR-mutated cancer

Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of multiple parallel RTKs further enhances EGFR-TKI e...

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Vydáno v:eLife
Hlavní autoři: Theard, Patricia L, Sheffels, Erin, Sealover, Nancy E, Linke, Amanda J, Pratico, David J, Kortum, Robert L
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2020
Témata:
Cancer Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7478890/
https://ncbi.nlm.nih.gov/pubmed/32897190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58204
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