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Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases
Engineering polyketide synthases (PKS) to produce new metabolites requires an understanding of catalytic points of failure during substrate processing. Growing evidence indicates the thioesterase (TE) domain as a significant bottleneck within engineered PKS systems. We created a series of hybrid PKS...
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| Опубликовано в: : | Angew Chem Int Ed Engl |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7395861/ https://ncbi.nlm.nih.gov/pubmed/32357274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202004991 |
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