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In vivo anticancer activity of a rhodium metalloinsertor in the HCT116 xenograft tumor model
Mismatch repair (MMR) deficiencies are a hallmark of various cancers causing accumulation of DNA mutations and mismatches, which often results in chemotherapy resistance. Metalloinsertor complexes, including [Rh(chrysi)(phen)(PPO)]Cl(2) (Rh-PPO), specifically target DNA mismatches and selectively in...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7395490/ https://ncbi.nlm.nih.gov/pubmed/32661159 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006569117 |
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