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Rhodium metalloinsertor binding generates a lesion with selective cytotoxicity for mismatch repair-deficient cells
The DNA mismatch repair (MMR) pathway recognizes and repairs errors in base pairing and acts to maintain genome stability. Cancers that have lost MMR function are common and comprise an important clinical subtype that is resistant to many standard of care chemotherapeutics such as cisplatin. We have...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5502648/ https://ncbi.nlm.nih.gov/pubmed/28634291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706665114 |
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