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Rhodium metalloinsertor binding generates a lesion with selective cytotoxicity for mismatch repair-deficient cells
The DNA mismatch repair (MMR) pathway recognizes and repairs errors in base pairing and acts to maintain genome stability. Cancers that have lost MMR function are common and comprise an important clinical subtype that is resistant to many standard of care chemotherapeutics such as cisplatin. We have...
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| Published in: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
National Academy of Sciences
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5502648/ https://ncbi.nlm.nih.gov/pubmed/28634291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706665114 |
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