In vivo anticancer activity of a rhodium metalloinsertor in the HCT116 xenograft tumor model

Mismatch repair (MMR) deficiencies are a hallmark of various cancers causing accumulation of DNA mutations and mismatches, which often results in chemotherapy resistance. Metalloinsertor complexes, including [Rh(chrysi)(phen)(PPO)]Cl(2) (Rh-PPO), specifically target DNA mismatches and selectively in...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Threatt, Stephanie D., Synold, Timothy W., Wu, Jun, Barton, Jacqueline K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Physical Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395490/
https://ncbi.nlm.nih.gov/pubmed/32661159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006569117
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