Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency

Poly(ADP ribose) polymerase inhibitors (PARPi) have efficacy in triple negative breast (TNBC) and ovarian cancers (OCs) harboring BRCA mutations, generating homologous recombination deficiencies (HRDs). DNA methyltransferase inhibitors (DNMTi) increase PARP trapping and reprogram the DNA damage resp...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: McLaughlin, Lena J., Stojanovic, Lora, Kogan, Aksinija A., Rutherford, Julia L., Choi, Eun Yong, Yen, Ray-Whay Chiu, Xia, Limin, Zou, Ying, Lapidus, Rena G., Baylin, Stephen B., Topper, Michael J., Rassool, Feyruz V.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395437/
https://ncbi.nlm.nih.gov/pubmed/32651270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003499117
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