Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency

Poly(ADP ribose) polymerase inhibitors (PARPi) have efficacy in triple negative breast (TNBC) and ovarian cancers (OCs) harboring BRCA mutations, generating homologous recombination deficiencies (HRDs). DNA methyltransferase inhibitors (DNMTi) increase PARP trapping and reprogram the DNA damage resp...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: McLaughlin, Lena J., Stojanovic, Lora, Kogan, Aksinija A., Rutherford, Julia L., Choi, Eun Yong, Yen, Ray-Whay Chiu, Xia, Limin, Zou, Ying, Lapidus, Rena G., Baylin, Stephen B., Topper, Michael J., Rassool, Feyruz V.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395437/
https://ncbi.nlm.nih.gov/pubmed/32651270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2003499117
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