CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes

An oncogenic role for CHD4, a NuRD component, is defined for initiating and supporting tumor suppressor gene (TSG) silencing in human colorectal cancer. CHD4 recruits repressive chromatin proteins to sites of DNA damage repair, including DNA methyltransferases where it imposes de novo DNA methylatio...

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Publié dans:Cancer Cell
Auteurs principaux: Xia, Limin, Huang, Wenjie, Bellani, Marina, Seidman, Michael M., Wu, Kaichun, Fan, Daiming, Nie, Yongzhan, Cai, Yi, Zhang, Yang W., Yu, Li-Rong, Li, Huili, Zahnow, Cynthia A., Xie, Wenbing, Yen, Ray-Whay Chiu, Rassool, Feyruz V., Baylin, Stephen B.
Format: Artigo
Langue:Inglês
Publié: 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5587180/
https://ncbi.nlm.nih.gov/pubmed/28486105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.04.005
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